Creamy Chicken Florentine Artichoke Casserole

Creamy Chicken Florentine Artichoke Casserole: A Gastronomic Symphony

Prepare your taste buds for a culinary masterpiece with our Creamy Chicken Florentine Artichoke Casserole. This indulgent dish combines tender chicken, vibrant spinach, and savory artichoke hearts enveloped in a luscious, creamy sauce. In this comprehensive guide, we’ll navigate the steps to creating this flavorful casserole, delve into the nuances of ingredient selection, provide essential cook notes for culinary finesse, explore creative variations, and offer keto and low-carb versions to suit diverse dietary preferences.


For the Casserole:

  • 4 cups cooked chicken, shredded
  • 1 lb fresh spinach, chopped
  • 1 can (14 oz) artichoke hearts, drained and chopped
  • 1 cup mayonnaise
  • 1 cup sour cream
  • 1 cup grated Parmesan cheese
  • 1 cup shredded mozzarella cheese
  • 4 cloves garlic, minced
  • Salt and pepper to taste

For the Topping:

  • 1 cup crushed pork rinds (for keto version) or breadcrumbs (for traditional version)
  • 1/2 cup grated Parmesan cheese
  • 1/4 cup unsalted butter, melted


1. Preheat and Prep:

  • Preheat your oven to 375°F (190°C). Grease a 9×13-inch baking dish.

2. Combine Casserole Ingredients:

  • In a large mixing bowl, combine shredded chicken, chopped spinach, chopped artichoke hearts, mayonnaise, sour cream, grated Parmesan, shredded mozzarella, minced garlic, salt, and pepper. Mix until well combined.

3. Layering Magic:

  • Spread the mixture evenly in the prepared baking dish, ensuring a smooth surface.

4. Prepare the Topping:

  • In a separate bowl, combine crushed pork rinds or breadcrumbs (depending on your preference), grated Parmesan, and melted butter.

5. Top It Off:

  • Sprinkle the topping mixture evenly over the casserole, creating a golden, crunchy crust.

6. Bake to Perfection:

  • Bake in the preheated oven for 25-30 minutes or until the casserole is bubbly and the topping is golden brown.

7. Let It Rest:

  • Allow the casserole to rest for a few minutes before serving to let the flavors meld.

Cook Notes

Chicken Preparation:

  • Use rotisserie chicken for convenience, or cook and shred chicken breasts for a personalized touch.

Spinach Moisture:

  • Ensure spinach is thoroughly drained to prevent excess moisture in the casserole.

Artichoke Hearts:

  • Opt for artichoke hearts packed in water rather than oil for a lighter texture.

Topping Texture:

  • Adjust the topping ingredients to achieve the desired crunchiness—more butter for a softer topping or more crushed pork rinds/breadcrumbs for a crispier finish.


1. Mushroom Medley Addition:

  • Saute a mix of mushrooms and layer them between the chicken and spinach for an earthy undertone.

2. Sun-Dried Tomato Twist:

  • Add chopped sun-dried tomatoes to infuse a burst of sweetness and tang.

3. Italian Herb Infusion:

  • Introduce dried Italian herbs like oregano, thyme, and basil for an aromatic twist.

4. Pasta Power Play:

  • Mix cooked pasta into the casserole for a heartier meal.

Keto and Low-Carb Versions

Keto Chicken Florentine Artichoke Casserole:

Pork Rind Prowess:

  • Substitute crushed pork rinds for breadcrumbs in the topping to keep it keto-friendly.

Almond Flour Adaptation:

  • Replace breadcrumbs with almond flour for a low-carb alternative.

Creamy Avocado Option:

  • Blend avocado into the creamy mixture for added richness and healthy fats.

Low-Carb Chicken Florentine Artichoke Casserole:

Cauliflower Comfort:

  • Include cauliflower florets in the casserole for added bulk and a low-carb vegetable option.

Greek Yogurt Swap:

  • Use Greek yogurt instead of sour cream for a lower-carb creamy layer.

Nutty Crunch:

  • Sprinkle chopped nuts like almonds or pecans on top for a crunchy, low-carb texture.

In conclusion, the Creamy Chicken Florentine Artichoke Casserole is not just a dish—it’s a gastronomic symphony that harmonizes diverse flavors into a satisfying crescendo. Whether you follow the classic recipe, experiment with creative variations, or opt for keto and low-carb adaptations, this casserole is a testament to the culinary arts.

As you savor each spoonful of this creamy, indulgent creation, relish in the joy of crafting a meal that transcends the ordinary. Share it with loved ones, revel in the delightful textures, and celebrate the fusion of ingredients that transforms a simple casserole into a culinary masterpiece. 🍽️✨

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